成人ADHD患者tDCS的研究，Soterix HD-Explore正向模拟软件呈现F4-F3区域的电流可视化

由美国Soterix公司开发出的HD-Explore模拟仿真软件是目前市场占有率较高、发文较多的一款颅内电场模拟软件，该软件是利用功能性核磁共振扫描建立真实精确的大脑模型，通过有限元分析方法，利用拉普拉斯方程对脑内的电场进行模拟，让研究者得以了解电场在颅内的分布情况；

HD-Explore软件的有效性已通过功能性磁共振（Halko 2011）、神经电生理学实验（Edwards 2013）、头皮表层电位记录（Datta 2013）、颅内电极记录（Huang 2013）的验证。

1.功能特点

l 独立软件、精准度高，模拟结果可以同超级计算机上运行的专业编程工具相媲美。

l 操作简单、使用方便，仅需简单的三个步骤，就可以获得详尽的电场分布情况。

l 支持个性化脑模定制，软件提供了MRI数据导入功能，让研究者进行个性化的研究。

l 2D和3D两种视图模式，全方位查看电场流向

l 动物实验模型，支持对灵长类动物（大鼠、猴子）电刺激实验结果的模拟。

The same breakthrough that allows instant current flow solutions making

HD-Explore™, the only software that can do simulation for any tDCS, tES, HD-tDCS and HD-tES montage.

文献参考：

HD-Explore™ is the only research grade software used in hundreds of research publications including:

• Single session tDCS over the left DLPFC disrupts interference processing. Brain Cogn 2018

• Autism-relevant traits interact with temporoparietal junction stimulation effects on social cognition: a high-definition transcranial direct current stimulation and electroencephalography study. Eur. J. Neurosci. 2017

• Modulating what is and what could have been: The effect of transcranial direct current stimulation on the evaluation of attained and unattained decision outcomes. Cogn Affect Behav Neurosci 2017

• Strengthening of Existing Episodic Memories Through Non-invasive Stimulation of Prefrontal Cortex in Older Adults with Subjective Memory Complaints. Front Aging Neurosci 2017

• Non-invasive brain stimulation targeting the right fusiform gyrus selectively increases working memory for faces. Brain Cogn 2017

• Transcranial direct current stimulation of superior medial frontal cortex disrupts response selection during proactive response inhibition. Neuroimage 2017

• Probing the causal role of prestimulus interregional synchrony for perceptual integration via tACS. Sci Rep 2016

• Transcranial direct current stimulation for the treatment of primary progressive aphasia: An open-label pilot study. Brain Lang 2016

• Feedback-Controlled Transcranial Alternating Current Stimulation Reveals a Functional Role of Sleep Spindles in Motor Memory Consolidation. Curr. Biol. 2016

• Exploratory study of once-daily transcranial direct current stimulation (tDCS) as a treatment for auditory hallucinations in schizophrenia. Eur. Psychiatry 2016

• Measurements and models of electric fields in the in vivo human brain during transcranial electric stimulation. Huang Y, Liu AA, Lafon B, Friedman D, Dayan M, Wang X, Bikson M, Doyle WK, Devinsky O, Parra LC. Elife 2017

• Transcranial Direct Current Stimulation Facilitates Associative Learning and Alters Functional Connectivity in the Primate Brain. Krause MR, Zanos TP, Csorba BA, Pilly PK, Choe J, Phillips ME, Datta A, Pack CC. Curr. Biol. 2017

• On comparing in vivo intracranial recordings in non-human primates to predictions of optimized transcranial electrical stimulation. Datta A, Krause MR, Pilly PK, Choe J, Zanos TP, Thomas C, Pack CC. Conf Proc IEEE Eng Med Biol Soc 2016

• Imaging artifacts induced by electrical stimulation during conventional fMRI of the brain. Antal A, Bikson M, Datta A, Lafon B, Dechent P, Parra LC, Paulus W. Neuroimage 2014

• Validation of finite element model of transcranial electrical stimulation using scalp potentials: implications for clinical dose. Datta A, Zhou X, Su Y, Parra LC, Bikson M. J Neural Eng 2013

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